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DNA Microarray Wet Lab Simulation Brings Genomics into the High School Curriculum

A. Malcolm Campbell^*,, Carolyn A. Zanta, Laurie J. Heyer^,, Ben Kittinger^*, Kathleen M. Gabric^||, and Leslie Adler^¶

Departments of *Biology and Mathematics and Genome Consortium for Active Teaching, Davidson College, Davidson, NC 28035-7118; Howard Hughes Medical Institute Biotechnology Education and Outreach Program, University of Illinois at Urbana-Champaign, Urbana, IL 61801; ^||Hinsdale Central High School, Hinsdale, IL 60521; and ^¶Montgomery County Public School District, Rockville, MD 20850

Monitoring Editor: Barbara Schulz

Address correspondence to: A. Malcolm Campbell (macampbell{at}davidson.edu)

We have developed a wet lab DNA microarray simulation as part of a complete DNA microarray module for high school students. The wet lab simulation has been field tested with high school students in Illinois and Maryland as well as in workshops with high school teachers from across the nation. Instead of using DNA, our simulation is based on pH indicators, which offer many ideal teaching characteristics. The simulation requires no specialized equipment, is very inexpensive, is very reliable, and takes very little preparation time. Student and teacher assessment data indicate the simulation is popular with both groups, and students show significant learning gains. We include many resources with this publication, including all prelab introductory materials (e.g., a paper microarray activity), the student handouts, teachers notes, and pre- and postassessment tools. We did not test the simulation on other student populations, but based on teacher feedback, the simulation also may fit well in community college and in introductory and nonmajors' college biology curricula.

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				A. M. Campbell, W. T. Hatfield, and L. J. Heyer Make Microarray Data with Known Ratios CBE Life Sci Educ, September 1, 2007; 6(3): 196 - 197. [Full Text] [PDF]