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Money, Sex, and Drugs: A Case Study to Teach the Genetics of Antibiotic Resistance

Karen A. Cloud-Hansen^*,, Jason N. Kuehner^,, Lillian Tong, Sarah Miller^*, and Jo Handelsman^*

*Wisconsin Program for Scientific Teaching, Department of Bacteriology, Cellular and Molecular Biology Program, and Center for Biology Education, University of Wisconsin–Madison, Madison, WI 53706

Monitoring Editor: Debra Tomanek

Address correspondence to: Karen A. Cloud-Hansen (kach{at}bact.wisc.edu)

The goal of the work reported here was to help students expand their understanding of antibiotic resistance, the Central Dogma, and evolution. We developed a unit entitled "Ciprofloxacin Resistance in Neisseria gonorrhoeae," which was constructed according to the principles of scientific teaching by a team of graduate students, science faculty, and instructors. A variety of activities and assessments were used, including a case study, short lectures, and group problem-solving. Implementation of "Ciprofloxacin Resistance in Neisseria gonorrhoeae" in a college freshman seminar suggests these materials are useful in increasing understanding of complex biological topics and improving problem-solving abilities.