The National Institutes of Health publishes a series of science curriculum supplements for K-12 education that are available from their Web site free of charge (http://science.education.nih.gov/supplements). In this feature, we review two of the high school supplements, Human Genetic Variation and Cell Biology and Cancer. Overall, we find that they are both excellent resources that engage students in learning science content while emphasizing the impact of scientific breakthroughs on personal and public health. In this review, we highlight the many strong features of the curricula and point out instances in which teachers may wish to seek out supplemental, updated information.