I acknowledge the Colgate University Biology 212 students and University of Scranton Biology 350 students for efforts in carrying out this lab exercise. Thanks also to Biology faculty from Colgate University and the University of Scranton (J. Voltzow, T. Sweeney, M. Kainz, N. Pruitt, B. Hoopes, K. G. Belanger, and S. Geier) for work implementing this exercise and for helpful constructive criticisms; to S. Wente (Vanderbilt University) for sharing yeast strains and reagents; and to N. Pruitt and K. G. Belanger for critically reading this manuscript. Special thanks to Kathleen Baier for many hours of technical assistance and insight in the Biol 212 lab. This work was supported by funding from Colgate University and National Institutes of Health grant R05 GM-65107 (to K.D.B.).