We thank Amanda (Gnau) Seguin for the creative idea that enabled the study presented in this article. We thank Drs. Joseph Maleszewski, John Wilterding, James Smith, Cori Fata-Hartley, Diane Ebert-May, Janet Batzli, John Merrill, Merle Heideman, Karl Smith, Mimi Sayed, Sarah Loznak, and Duncan Sibley for helpful discussions about teaching and learning and assistance during this study. We also thank the many LAs who promoted and supported these interventions. Our cystic fibrosis research laboratory is supported by Cystic Fibrosis Foundation and Pennsylvania Cystic Fibrosis grants for our physiology cystic fibrosis research program; our STEM Learning laboratory is supported by Lilly and Quality grants from MSU and Course Curriculum and Laboratory Improvement and Transforming Undergraduate Education in Science grants from the National Science Foundation for our education research program.