This research was supported by the NSF under award number 1761179, the National Institutes of Health under award numbers R01HD084772 and P2CHD042849, and the Jacobs Foundation under award number 2019-1320-14. C.A.H. is supported by the NSF Postdoctoral Research Fellowship under grant number 2004831. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NSF, the National Institutes of Health, or the Jacobs Foundation. We thank Dustin Thoman and Kristin Patterson for their thoughtful feedback and suggestions on an earlier draft of this article.