The development of the original version of Biofundamentals (MCDB 1111) was carried out as part of a sabbatical project and was made possible through generous gifts from Spencer I. Browne and Hillary L. Browne. Data from the BCI project (NSF 0405007) were used to inform the original design of the course. The development of the beSocratic system was funded through NSF projects DUE 1341987and DUE 1043707. We have benefited from the involvement and insights of a number of colleagues, particularly Tristan McClure-Begley and Jennifer Martin; learning assistants; and graduate teaching assistants, particularly Joe Rokicki; and from the work of Natalie Jones, who designed the original beSocratic activity on genetic drift.